Polynucleotide Treatment in Birmingham
Clinician-led skin regeneration using Vitaran and Plinest — now available at Hello Skin Clinic.
Polynucleotides are one of the most talked-about advances in aesthetic medicine — and for good reason. Unlike treatments that add volume or fill lines temporarily, polynucleotides work with your skin’s own biology to support regeneration from within. At Hello Skin Clinic, we now offer polynucleotide treatments in Birmingham, delivered by our clinical team with a free in-person consultation before every course.
Free in-person consultation required before treatment. Individual results may vary.
What Are Polynucleotides?
Polynucleotides are highly purified chains of DNA fragments — typically derived from salmon or trout DNA — that are biocompatible with human tissue. When injected into the skin, they act as biological signals that support the activity of fibroblasts: the cells responsible for producing collagen and elastin.
Unlike dermal fillers, which physically add volume, or skin boosters like Profhilo, which hydrate using hyaluronic acid, polynucleotides work at a cellular level. They don’t add anything artificial — they support your skin’s own processes. The result, over a course of treatments, may include improvements in skin firmness, texture, hydration, and overall quality.
At Hello Skin Clinic, we use Vitaran polynucleotides for facial treatments and Plinest for the delicate under-eye area — two of the most clinically established polynucleotide products available in the UK.
Polynucleotide Treatments — Face, Under Eyes & Hair
Polynucleotides for Face — Vitaran
Our facial polynucleotide treatments use Vitaran — a well-established product used widely across Europe for skin quality improvement. Vitaran is particularly suited to addressing fine lines, loss of firmness, and dull or uneven skin texture across the face, neck, and décolletage.
A typical course involves two to three sessions, spaced four weeks apart, with visible changes in skin quality developing gradually over six to eight weeks as the regenerative process builds.
Polynucleotides for Under Eyes — Plinest
The under-eye area is one of the most requested treatment zones for polynucleotides — and one of the most technically demanding. We use Plinest specifically for this area, chosen for its fine formulation that makes it suitable for the thin, delicate skin beneath the eyes.
Polynucleotides around the eye area may help with the appearance of hollowness, fine lines, and skin crepiness that can make the eyes look tired. This is a gradual process — results typically become noticeable from four to six weeks after the first session.
Polynucleotides for Hair — Nucleofill
We also offer Nucleofill polynucleotide scalp treatments as part of our hair restoration programme — supporting scalp health and hair follicle environment as a complement to PRP hair therapy. Ask about this during your consultation.
What to Expect at Your Polynucleotide Appointment
Step 1
Free In-Person Consultation
Every polynucleotide treatment at Hello Skin Clinic begins with a free in-person consultation. Your clinician will assess your skin, discuss your concerns and goals, and recommend the most appropriate product and treatment plan for you. There is no obligation to proceed.
Step 2
Preparation
Before treatment, a topical numbing cream is applied to the area to minimise discomfort. The skin is cleaned and prepped to clinical standards. The appointment typically takes 45 to 60 minutes in total including consultation time on your first visit.
Step 3
The Injection
Polynucleotides are administered via a series of small, precise injections into the treatment area. The number of injection points varies depending on the area being treated. Most clients describe the sensation as mild and well-tolerated.
Step 4
Aftercare & Recovery
There is typically minimal downtime following polynucleotide treatment. Some redness, mild swelling, or small bumps at injection sites are normal in the hours following treatment and usually settle within 24 to 48 hours. Your clinician will provide full written aftercare instructions.
Step 5
Results Over Time
Polynucleotides work gradually. Unlike fillers, you won’t see an immediate dramatic change — and that’s by design. Improvements in skin quality, firmness, and hydration typically develop over four to eight weeks as the biological process progresses. Most clients complete a course of two to three sessions for optimal results.
Polynucleotides vs Profhilo — What's the Difference?
Both polynucleotides and Profhilo are injectable skin boosters — but they work differently and suit different concerns.
Profhilo uses high-concentration hyaluronic acid to intensely hydrate the skin and stimulate collagen production through a process called bio-remodelling. It works relatively quickly and is particularly effective for overall skin laxity and hydration in patients whose skin has lost density with age.
Polynucleotides use purified DNA fragments to signal fibroblast activity at a cellular level. They work more gradually than Profhilo but are particularly well-suited to targeted concerns — such as under-eye hollowness, fine lines in specific areas, and skin quality in zones where Profhilo cannot easily be placed.
In some cases, our clinicians may recommend both treatments as part of a complementary programme. The right choice depends on your skin, your concerns, and your goals — which is why we always begin with a free in-person consultation.
Polynucleotide Treatment — Frequently Asked Questions
What are polynucleotides used for?
Polynucleotides are used to support skin regeneration, improve skin quality, and address concerns such as fine lines, loss of firmness, under-eye hollowness, skin crepiness, and overall skin texture. They are also used in scalp treatments to support hair follicle health.
How long do polynucleotides take to work?
Polynucleotides work gradually. Most clients begin to notice improvements in skin quality from four to six weeks after their first session, with more significant changes developing over the full course of treatment. A typical course is two to three sessions spaced four weeks apart.
How long do polynucleotides last?
Results from a course of polynucleotide treatment may last up to 12 months, depending on individual skin condition, lifestyle, and the number of sessions completed. Maintenance sessions are available to sustain results over time.
Do polynucleotides work?
Polynucleotides have been used in regenerative medicine for decades and are well-established in European aesthetic practice. Clinical studies support their role in improving skin quality markers including hydration, elasticity, and collagen density. Individual results vary depending on skin condition, age, and the course of treatment completed.
What are the side effects of polynucleotides?
Common side effects include temporary redness, mild swelling, and small bumps at injection sites, which typically resolve within 24 to 48 hours. As with any injectable treatment, bruising may occur. Serious complications are rare when treatment is administered by a qualified clinician. Your practitioner will discuss all potential risks during your consultation.
Can polynucleotides go wrong?
When administered by a qualified clinician following a thorough consultation, polynucleotide treatment carries a low risk of serious complications. The most common issues — temporary swelling, redness, or bruising — are minor and resolve quickly. At Hello Skin Clinic, every treatment is preceded by a free in-person consultation to assess suitability and minimise risk.
What is the aftercare for polynucleotides?
Following polynucleotide treatment, we recommend avoiding strenuous exercise, excessive heat (saunas, steam rooms), and alcohol for 24 hours. Avoid touching or pressing the treated area. Sun protection is important in the weeks following treatment. Full written aftercare instructions are provided at your appointment.
How much does polynucleotide treatment cost in Birmingham?
Pricing for polynucleotide treatment at Hello Skin Clinic is confirmed during your free in-person consultation, as the recommended course varies depending on your skin and treatment area. Book a free consultation via WhatsApp or call 0121 714 0999 to discuss your options with no obligation.
Do’s and Don'ts Before and After Polynucleotides Treatment
Before your Appointment
Do’s
Drink plenty of water to ensure your skin is well-hydrated.
Inform us of any allergies (especially fish) or medications you are taking.
Eat a light meal before your session.
Don’t’s
Drink alcohol 24 hours prior to treatment to minimize the risk of bruising.
Use active skincare (retinol or acids) for 48 hours before your appointment
After your Appointment
Do’s
Keep the area clean and hydrated.
Use a gentle cold compress if you experience minor swelling.
Don’t’s
Touch or massage the treated area for at least 24 hours.
Engage in strenuous exercise, saunas, or steam rooms for 48 hours.
Apply makeup to the treated area for 12–24 hours to prevent infection.
Consume alcohol or caffeine for 24 hours after your treatment.
What Birmingham Clients Say About Us
Real experiences from real people. Individual results may vary.
Meet The Team
Tekla
Tekla is our Director and resident skin expert. A Level Six Beauty and Aesthetics Practitioner with over five years of experience, she specialises in advanced aesthetics treatments, including laser therapies, injectables and targeted fat loss treatments. Tekla combines her extensive expertise with personalised care, to deliver exceptional results.
About Hello Skin Clinic
At Hello Skin Clinic, we offer a luxurious, relaxing environment while delivering exceptional results for our clients.
If you’re considering polynucleotides in Birmingham, Hello Skin Clinic may be the solution for you. Our experienced aesthetic practitioners begin your treatment with a comprehensive consultation, ensuring every procedure is perfectly tailored to achieve beautiful, natural results just for you.
How to Find Us
Visit us in our luxury Birmingham City Centre clinic, conveniently located a short walk from Brindley Place.
Parking is available on street near the clinic, or at the Arena Birmingham – South car park just a minute’s walk away.
We strive to provide a luxurious, relaxing environment for all our clients. That’s why our clinic is rated five stars by our customers on Google. So get in touch today to find out why we are the clinic of choice for Polynucleotides in Birmingham!